PEBC (PHARMACEUTICAL SCIENCES) Sample Questions
Categories: PEBC Canada
Ques. All of the following statements concerning the lyophilization of a parenteral product are correct,
EXCEPT:
a. there is minimal loss of activity in heat labile materials.
b. the liquid must be frozen to below the eutectic temperature.
c. the solute usually forms an amorphous glass.
d. the eutectic temperature is the freezing point of the drug solution.
e. water is removed from the frozen mixture by sublimation.
Ques. Dopamine is useful in the treatment of cardiogenic shock because it:
a. selectively dilates renal and mesenteric vascular beds.
b. does not induce peripheral vasoconstriction.
c. decreases the force of myocardial contraction.
d. delays the atrioventricular (AV) conduction time.
e. prolongs the QT interval on the ECG.
Ques. Concentration of a drug in breast milk exceeds that in plasma, if the drug:
a. is basic.
b. is protein bound.
c. is acidic but not protein bound.
d. has a small volume of distribution.
e. has a large volume of distribution.
Ques. Drug A is administered by continuous IV infusion at a rate of 2 mg/min. It has an average half-life of 1.5 h and a volume of distribution of 150 L in an average 70 kg patient. Using this information, what is the steady-state concentration of Drug A in plasma?
a. 1.5 mg/L
b. 1.7 mg/L
c. 2.1 mg/L
d. 2.4 mg/L
e. 2.7 mg/L
Ques. Which of the following medications induces an isoform of cytochrome P450?
a. Carbamazepine
b. Clarithromycin
c. Amiodarone
d. Metronidazole
e. Bosentan
Ques. Diazepam Injection U.S.P
Diazepam5 mg/ml
Ethanol 10%
Propylene glycol 40%
Benzyl alcohol 1.5%
Water for Injection qs 100%
In the formulation given above, propylene glycol functions as a(n):
a. emulsifier
b. antioxidant.
c. cosolvent.
d. buffer.
e. preservative.
Ques. Which of the following directly influences the in vitro physical stability of an oil-in-water emulsion in which the drug is incorporated in the dispersed phase?
a. Amount of preservative added
b. Molecular weight of the drug
c. Solubility of the emulsifier in water
d. Particle size of the internal phase
e. Type of suspending agent used
Ques. Abatacept acts by:
a. stimulating adenosine receptors.
b. binding to MHC Class II on B cells.
c. inhibiting B cell receptors.
d. activating T cell receptors.
e. binding CD80/86 on antigen-presenting cells.
Ques. With respect to bioequivalence, the parameter “Cmax” is:
a. affected by the extent of absorption only.
b. affected by the rate of absorption only.
c. affected by neither rate nor extent of absorption.
d. affected by both rate and extent of absorption.
e. the only significant parameter.
Ques. Five subjects given a single intravenous dose of a drug have the following elimination half-lives: 3, 9, 6, 5, and 4 h (hours). The mean half-life is:
a. 4 h.
b. 5 h.
c. 5.4 h.
d. 5.8 h.
e. 6 h.