PEBC (Pharmaceutical Sciences) Sample Questions

10 October, 2022

Categories: PEBC Canada

Ques. Which of the following statements is correct about transdermal drug administration?

a. Most drugs can permeate the skin and enter the systemic circulation.

b. Transdermal absorption achieves a fast onset of drug action.

c. The skin is tolerant to most drugs and chemicals in transdermal delivery systems.

d. Transdermal administration produces minimal variations in drug absorption.

e. Hair follicles are a determinant in limiting transdermal drug absorption.

Ques. Which of the following drugs is an antagonist at the central presynaptic alpha2-adrenergic receptors?

a. Clonidine

b. Terazosin

c. Mirtazapine

d. Risperidone

e. Venlafaxine

Ques. A monoclonal antibody was tested in patients using the following dose ranges and resulted in the following t1/2 values:

Dose Half-life

0.2 mg/kg 2 days

1 mg/kg 8 days

2 mg/kg 18 days

3 mg/kg 18 days

5 mg/kg 18 days

What is the reason for the dose-dependent t1/2? The biologic drug:

a. eliminates primarily by the lymphatic system at lower doses.

b. eliminates primarily by the liver resulting in nonlinear pharmacokinetics.

c. eliminates by catabolism.

d. distributes rapidly to peripheral organs at lower doses.

e. exhibits target-mediated drug disposition.

Ques. Pravastatin inhibits:

a. PCSK9 protein.

b. lipoprotein lipase.

c. vascular oxidative stress.

d. scavenger receptor function.

e. HDL synthesis.

Ques. In a manufacturing setting, which of the following methods is the most appropriate to use for sterilization of plastic (PVC) tubing?

a. Dry heat

b. Steam autoclave

c. lonizing radiation

d. Ethylene oxide gas

e. Filtration

Ques. What is the first process used when evaluating the integrity of a recombinant protein after each purification step?

a. ELISA

b. Quantitative PCR

c. Peptide mapping

d. SDS-polyacrylamide gel electrophoresis

e. Amino acid sequencing

Ques. Which of the following types of neurotransmitter receptors is most responsible for the decreased risk of extrapyramidal side effects observed with some second generation antipsychotics relative to first generation antipsychotics?

a. Serotonergic

b. Histaminergic

c. Muscarinic

d. Noradrenergic

e. Alpha-adrenergic

Ques. In tablets made from wet granulation processing, which of the following substances is commonly included as a lubricant?

a. Lactose

b. Potato starch

c. Croscarmellose

d. Dicalcium phosphate

e. Sodium lauryl sulfate

Ques. Permeation enhancers increase drug absorption from buccal dosage forms by which of the following mechanisms?

a. Decreasing drug solubility

b. Extracting oral mucosal lipids

c. Disrupting saliva secretion

d. Increasing drug particle size

e. Prolonging oral retention

Ques. Disintegration of a compressed tablet is primarily dependent upon which of the following properties of the tablet?

a. Size

b. Shape

c. Hardness

d. Coating

e. Stability

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