PEBC (Psychiatric and Neurological Drugs) Sample Questions Set-8

8 October, 2022

Categories: PEBC Canada

Ques. After her phenytoin therapy has been optimized, MP returns to the clinic just before her wedding and requests an oral contraceptive. Which of the following statements regarding oral contraceptives and phenytoin is most correct?

A. There is no potential drug-drug interaction

B. Phenytoin inhibits the metabolism of phenytoin and may increase their side effects.

C. Oral contraceptives inhibit the metabolism of phenytoin and may increase its side effects.

D. Phenytoin induces the metabolism of oral contraceptives and may decrease their efficacy.

E. Oral contraceptives induce the metabolism of phenytoin and may decrease its efficacy.

Answer: (d)

Ques. Doctor doubled dose of phenytoin, when to measure steady state concentration?

A) After 1 day

B) After 1 week

C) After 1 month

D) After 2 week

E) After 3 week

Answer: (b)

Ques. A 21-year-old obese woman who is otherwise healthy reports a 5-year history of Generalized-onset seizures are most effectively treated with broad-spectrum antiepileptic drugs. Her current medications include Alesse 28, 1 tablet daily as directed (has not had this filled regularly), vitamin C 500 mg po od, and vitamin B complex 50 1 tab po daily. What is the drug of choice for generalized onset seizures?

A) Lamotrigine

B) valproic acid

C) Carbamazepine

D) Phenytoin

E) Topiramate

Answer: (b)

Ques. All of the following drugs have least drug interactions with Alesse 28?

I) Valproic acid

II) Gabapentin

III) Lamotrigine

A) I only

B) III only

C) I and II

D) II and III

E) I, II, III

Answer: (e)

Ques. Which of the following laboratory tests is monitored for valporoic acid?

A) Renal function tests

B) Liver function tests

C) Fabrile seizure

D) Neuroleptic malignant syndrome

Answer: (b)

Ques. A patient brings a prescription of divalproex 250 mg bid. In the patient profile the patient was using valproic acid for the past 3 years. What is appropriate to do?

A) this could be drug non compliance

B) call doctor to confirm if dr want to change medication

C) valproic acid and divalproex are drug with same indication so dispense

D) Check dosage if it is same as divalproex than can be dispensed

E) ask patient if he is aware his medication has been changed and what did the doctor tell you about this

Answer: (e)

Ques. A 60 yo person on Li2CO3 600 mg q8h for manic depression, have continuous vomiting and watery diarrhea for the last 1 week? Looking for some OTC antidiarrheal? If a patient is taking it mistakenly every 1 h, what serious symptoms are observed?

A) bradycardia

B) sweating

C) confusion

D) diarrhea

E) coarse tremors

Answer: (e)

Ques. A resident of a long term care facility was admitted to hospital with behavioral challenges. The patient's condition stabilized on olanzapine 10 mg qid. After discharge from hospital, the resident required readmission a short time later because of over sedation and falls. What is the reason for second time admission?

A) due to side effect of olanzapine

B) neuroleptic malignant syndrome

C) overdose of olanzapine

D) because patient is old

E) not sure what is going on

Answer: (c)

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