PEBC (Pharmaceutical Sciences) Sample Questions

9 October, 2022

Categories: PEBC Canada

Ques. Reasons for using coatings on tablets include all of the following, EXCEPT:

a. to mask the taste of the drug.

b. to mask the odor of the drug.

c. to improve the appearance of the tablet.

d. to increase the drug's release rate.

e. to protect the drug from stomach acid.

Ques. Which of the following terms indicates a loss of moisture?

a. Deliquescence

b. Efflorescence

c. Hygroscopicity

d. Polymorphism

e. Condensation

Ques. Which of the following statements is FALSE regarding tablet formulation?

a. Diluents are fillers to add bulk to the tablet.

b. Lubricants help the patient to swallow the tablet more easily.

c. Binding agents may be added dry or in solution.

d. Disintegrants draw water into the tablet causing it to burst.

e. Glidants promote the flow of materials during compression.

Ques. Factors that determine bioequivalence of two brands of a drug include the:

a. taste of the preparations.

b. physical appearance of the preparations.

c. pharmacokinetic parameters of the preparations.

d. cost of the preparations.

e. package size of the preparations.

Ques. The total body clearance of a drug is 200 mL/min in a normal healthy adult and the renal clearance is 10mL/min. This is most likely explained by the fact that the drug:

a. is extensively metabolized.

b. accumulates in patients with moderate renal failure

c. undergoes significant entero-hepatic recycling.

d. is not bound to plasma proteins.

e. is concentrated in adipose tissue.

Ques. Imatinib is an anticancer agent used in the treatment of chronic myelogenous leukemia that acts by inhibiting the activity of:

a. tyrosine kinase of Bcr-Abl.

b. tyrosine kinase of HER-2.

c. tyrosine kinase of FGFR.

d. histone deacetylases.

e. serine/threonine kinase mTOR.

Ques. Which of the following diuretics is used to block the Na+-H+ exchange system of the renal tubule?

a. Furosemide

b. Hydrochlorothiazide

c. Spironolactone

d. Acetazolamide

e. Amiloride

Ques. Atropine poisoning can be recognized by all of the following signs or symptoms, EXCEPT:

a. dry skin.

b. flushed appearance.

c. delirium and restlessness.

d. mydriasis.

e. diarrhea.

Ques. The organophosphates commonly found in insecticides are thought to act by which of the following mechanisms?

a. combining with acetylcholine

b. Potentiating the action of acetylcholinesterase

c. Forming a very stable complex with acetylcholinesterase

d. Reacting at the cholinergic receptor

e. Preventing the release of acetylcholine from the nerve ending

Ques. Which of the following is a selective adrenergic beta1-blocker with endothelium-dependent vasodilating properties?

a. Nebivolol

b. Metoprolol

c. Acebutolol

d. Nadolol

e. Carvedilol

Ques. Which of the following statements is correct regarding the use of monoclonal antibody drug therapies?

a. Flu-like symptoms commonly occur at the start of therapy.

b. T cells are stimulated and will initiate a host rejection process.

c. Adalimumab is a murine-derived immunoglobulin monoclonal antibody product. d. Use of chimeric monoclonal antibodies is associated with increased immunogenicity.

e. Use of Fc fragments avoids raising an immune response against the FAB part.

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