PEBC (Pharmaceutical Sciences) Sample Questions

10 October, 2022

Categories: PEBC Canada

Ques. In some parenteral formulations, sodium metabisulphite is included as:

a. an antioxidant

b. a chelator.

c. a solubilizer.

d. a cosolvent

e. an emulsifier.

Ques. The carbonic anhydrase inhibitor dorzolamide is structurally classified as a:

a. biguanide.

b. butyrophenone.

c. sulfonamide.

d. sulfonylurea.

e. thiazolidinedione.

Ques. Which of the following statements is FALSE regarding virus vectors used in the production of biotechnology drugs?

a. Viruses can be introduced by nutrients.

b. Viruses can be generated by an infected production cell line.

c. The most frequent source of virus introduction is the growth media.

d. Viruses can be inactivated by physical or chemical treatment of the product.

e. There is a trend toward using better-defined growth media in which serum levels are significantly reduced.

Ques. Which of the following excipients is NOT commonly found in biotechnology formulations?

a. Albumin

b. Lysine

c. Tween 20

d. Saline

e. Phosphate

Ques. An angiotensin-converting enzyme (ACE) inhibitor for which both renal elimination and metabolism are important in the elimination of the drug and its active metabolites is:

a. enalapril.

b. fosinopril.

c. lisinopril.

d. quinapril.

e. ramipril.

Ques. Once daily dosing of aminoglycosides is effective due to:

a. prolonged residence of the antibiotic in the body.

b. post-antimicrobial effect.

c. enhanced tissue accumulation.

d. reduced renal clearance.

e. higher peak-trough differences.

Ques. How much NaCl is required to make 100 mL of isotonic 0.5% phenylephrine HCl solution? (NaCl equivalent of phenylephrine HCl is 0.32)

a. 100 mg

b. 300 mg

c. 500 mg

d. 740 mg

e. 900 mg

Ques. Which of the following nonparenteral routes of administration yields the best bioavailability of biotechnology protein drugs?

a. Oral

b. Rectal

c. Ocular

d. Pulmonary

e. Transdermal

Ques.Theoretically, the shelf life of a pharmaceutical tablet preparation is best measured by a change in which of the following?

a. Permeability of the drug

b. Dissolution of the drug

c. Strength of the drug

d. Solubility of the drug

e. Partitioning of the drug

Ques. A drug that is considered to be low clearance and is metabolized entirely by the liver is sensitive to changes in:

a. drug binding to plasma proteins.

b. bile secretion.

c. hepatic blood flow.

d. renal blood flow.

e. P-glycoprotein transport activity.

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