PEBC (Therapeutic) Sample Questions

17 October, 2022

Categories: PEBC Canada

Ques. A 22-year-old woman, otherwise healthy, presents with a 6-month history of episodes of unresponsiveness accompanied by lip smacking lasting 1 to 2 minutes and occurring 2 to 3 times per month. She takes no medications She is in a monogamous relationship with a male sexual partner and only occasionally uses contraception. A routine EEG shows left temporal epileptiform activity and MRI of the brain shows left mesial temporal sclerosis. Which of the following drugs have decreased the effectiveness of oral contraceptive pills?

i. Gabapentin

ii. Lamotrigine

iii. Topiramate

a) I only

b) III only

c) I and II

d) II and III

e) I, II III

Answer: (d)

Ques. Which of the following side effects of phenytoin therapy is not related to increased serum concentrations?

I) Ataxia

II) Sedation

III) Hirsutism

a) I only

b) III only

c) I and II only

d) II and III only

e) I, II and III

Answer: (b)

Ques. After her phenytoin therapy has been optimized, ZM returns to the clinic just before her wedding and requests an oral contraceptive. Which of the following statements regarding oral contraceptives and phenytoin is most correct?

A. There is no potential drug-drug interaction

B. Phenytoin inhibits the metabolism of phenytoin and may increase their side effects.

C. Oral contraceptives inhibit the metabolism of phenytoin and may increase its side effects.

D. Phenytoin induces the metabolism of oral contraceptives and may decrease their efficacy.

E. Oral contraceptives induce the metabolism of phenytoin and may decrease its efficacy.

Answer: (d)

Ques. Doctor doubled dose of phenytoin, when to measure steady state concentration?

A) After 1 day

B) After 1 week

C) After 1 month

D) After 2 week

E) After 3 week

Ques. KM is a 75 yo woman, frequently forgets daily activities such housekeeping, names of relatives and friends... Doctor diagnosed Alzheimer's. What is the goal of therapy?

A) Delay the time to transfer nursing home facility

B) Decrease mortality

C) Decrease cognitive functions damage

D) Decrease the time for pharmacotherapy

E) Increase medication compliance

Answer: (c)

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