PEBC (Neurological Drugs & Respiratory Drugs) Sample Questions Set-8
Categories: PEBC Canada
Question. A.M. is an 18-year old male who was admitted to the hospital after having his first psychotic break. A.M. 's parents noticed that he was acting strangely for the last few months. His grades in school had dropped; he was not interested in hanging out with his friends anymore; and he had been fired from his part-time job. Most of A.M.’s time was spent alone in the basement staring blankly at the TV. When it appeared that A.M. was not responding to external stimuli, his parents brought him to the emergency department worried that something is wrong with their son. A.M.’s social withdrawal, as well as his loss of academic and occupational functioning is most consistent with:
a) prodromal phase of schizophrenia
b) depression
c) acute phase of schizophrenia
d) residual phase of schizophrenia
Answer. (a)
Question. As part of the initial screening of the above patient, it would be important to include :
a. complete blood count and electrolytes
b. urine drug screen
c. urine culture
d. thyroid function test
Answer. (a)
Question. The most appropriate choice of medication treatment for A.M would be:
a) clozapine
b) olanzapine
c) perphenazine
d) chlorpromazine
Answer. (b)
Question. Second-generation anti-psychotics as a class offer the following advantage:
a) high D2 blockade
b) dopamine blockade specific to the nigrostriatal and mesocortical areas
c) Low ratio of D2:5HT2 blockade
d) Rapid dissociation from the serotonin receptor
Answer. (c)
Question. The efficacy of second-generation antipsychotics as compared to conventional antipsychotics can be summarized as:
a) equally effective for positive symptoms and negative symptoms, less effective for cognitive symptoms and mood symptoms
b) equally effective for positive, negative, cognitive and mood symptoms
c) equally effective for positive symptoms, more effective for mood and cognitive symptoms and less effective for negative symptoms
d) equally effective for positive symptoms, more effective for negative, cognitive and mood symptoms
Answer. (d)
Question. Which of the following second-generation agents is most likely to cause prolactin elevation?
a) Risperidone
b) Olanzapine
c) Quetiapine
d) Clozapine
Answer. (a)
Question. The propensity of second generation agents to cause weight gain can be ordered as follows:
a) clozapine>Risperidone>Quetiapine>olanzapine
b) olanzapine>clozapine>Risperidone>Quetiapine
c) risperidone>Quetiapine>olanzapine>clozapine
d) clozapine>Olanzapine>Quetiapine>Risperidone
Answer. (d)
Question. RJ a 34 year old patient who has been getting his prescriptions filled at your pharmacy for a long time. He has been taking paroxetine 40 mg per day for two years for the treatment of obsessive-compulsive disorder, with good results. He used to have obsessions of doubt, leading to compulsive checking, which virtually incapacitated him. He wasn’t able to leave the house for fear that the stove had been left on, or that the door wasn’t locked. He has talked to his psychiatrist about stopping the medication and he asks for your opinion.
Which of the following is correct?
a. he will not relapse after discontinuation since he took the medication for two years
b. he must stay on medication for at least five years to reduce the risk of relapse
c. he has been on medication too long already
d. he may or may not relapse if the medication is stopped.
Answer. (d)
Question. RJ after a discussion with his physician, decides to stop the paroxetine. Which of the following would represent the best advice for him?
a. taper down the dose of paroxetine slowly
b. stop the paroxetine at once and take prn doses of diazepam if required
c. stop the paroxetine at once and monitor symptoms
d. substitute paroxetine with fluoxetine for two weeks then stop
Answer. (a)
Question. One year after stopping the paroxetine, RJ notices the return of some of his symptoms. He is reluctant to take medication again because he does not want to have to take medications for the rest of his life.
Which of the following statements is correct with respect to treatment of OCD?
a) cognitive-behavioral therapy has not been shown to be effective
b) cognitive-behavioral therapy is as effective as pharmacotherapy
c) pharmacotherapy is much more effective than cognitive-behavioural therapy
d) cognitive-behavioral therapy should be tried before pharmacotherapy is offered
Answer. (d)