PEBC (Neurological Drugs & Respiratory Drugs) Sample Questions Set-10

7 November, 2022

Categories: PEBC Canada

Question. MP is a 78 year old female who had difficulty sleeping over the past several days and some leg cramping and rigidity in the early hours of morning. Her medical history includes angina, chronic constipation and Parkinson's disease. Currently she is using levodopa/carbidopa 100/25 1 tablets 8 am 12 noon 4 pm and 8 pm. Amantadine 100 mg qd, ASA 81 mg, Nitrodur 0.6 mg qam, bisacodyl PRN.

Which of the following is the most likely explanation for MP symptoms?

A) anticholinergic side effects of amantadine

B) On-off fluctuation

C) Wearing off effect

D) Extra pyramidal side effects

E) levodopa induced urinary incontinence

Answer. (c)

Question. Which of the following do you suggest to improve MP symptoms?

A) Decrease the dose of levodopa/carbidopa

B) Switch to controlled release levodopa/carbidopa

C) Switch to amantadine

D) decrease the frequency of levodopa/carbidopa

E) Discontinue levodopa and add entacapone

Answer. (b)

In these questions inclusive refer to the following:

KM is a 66-year-old female who visits your pharmacy. She arrives at your pharmacy to refill her prescriptions. She is currently taking levodopa/carbidopa 100/25 five times daily, bromocriptine 5 mg qid, and selegiline 5 mg q 12 h. KM tells you that she has been well, except for some difficulty sleeping.

Question. What should you recommend to KM?

a) Ensure that selegiline is taken early in the day

b) Ensure that the last dose of levodopa is taken to no later than 6 pm

c) Suggest that you could recommend that her physician switch from bromocriptine to ropinirole

d) Ensure that she avoids foods with high tyramine content, such as red wine and smoked meats.

Answer. (a)

Question. KM turns one month later with a new complaint. She tells you that she has noticed that she is often light-headed when she arises from sitting or lying down. What might be causing this problem for KM?

a) Progression of PD

b) Levodopa therapy

c) Bromocriptine therapy

d) All of the above

Answer. (d)

Question. Which of the following is a reasonable strategy for dealing with KM’s problem?

a) The use of a salt substitute

b) Fluid restriction

c) Fludrocortisone therapy

d) All of the above

Answer. (a)

Question. Which of the following medications is/are approved for postherpetic neuralgia (PHN)?

a. Gabapentin

b. Amitriptyline

c. Lidocaine patch 5%

d. All of the above

Answer. (d)

Question. Which of the following agents is indicated for the treatment of trigeminal neuralgia?

a. Topiramate

b. Gabapentin

c. Carbamazepine

d. Phenytoin

Answer. (c)

Question. Which of the following antidepressants is most effective in the treatment of neuropathic pain?

a. Amitriptyline

b. Fluoxetine

c. Paroxetine

d. citalopram

Answer. (a)

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